November 10, 2003 -- The Baker group, of the Howard Hughes Medical Institute and the University of Washington, is taking a combined molecular biological, biophysical and computational approach to the protein folding problem.
Our computational program, ROSETTA, uses a knowledge of non-homologous sequences and their solved three-dimensional structures, optimized by simulated annealing to create protein tertiary structures. One of the key ingredients of ROSETTA is a scoring function that assigns a score to three-dimensional structures and guides the search from the extended chain to a protein-like fold. We knew that the efficient development of ROSETTA required that our researchers, located at roughly ten different sites, interact, coordinate efforts, track bugs and implementation issues, and view the ROSETTA CVS repository. We believe codeBeamer provides a solution to our distributed development needs. It's rapid installation and configuration, as well as its intuitive interface reduce the time necessary for IT intervention and increase the time our researchers are focused upon the development of ROSETTA.

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